Myelodysplastic Syndromes (MDS) - 1483 Words

Not too long ago, a national, television journalist announced that they were diagnosed with something called MDS. It was the host of â€Å"Good Morning America†, Robin Roberts, who reported that she had recently been diagnosed with MDS or myelodysplastic syndrome. She also stated that she had acquired MDS as a result of her initial battle with breast cancer. Robin Roberts is not only a national TV personality, but she is also a local celebrity here on the Gulf Coast. I was captivated by this obviously emotional announcement and the heartfelt outpouring given by Robin on her television show in front of millions of people. Thus, my interest prompted further investigation of how myelodysplastic syndrome affects the bone marrow and blood cells. Journal research from scientific, scholarly sources was necessary to know and understand exactly what type of challenges Robin Roberts is about to face in the weeks ahead. The Investigation of MDS According to the MD Anderson Cancer Center (2009), Myelodysplastic Syndrome (MDS) is the name for a group of various disorders that affect the bone marrow. Bone marrow is where red blood cells, white blood cells and platelets are produced (MFMER, 2011). MDS primarily occurs in the elderly population in ages 65 and older, but MDS can affect younger patients as well. Bone marrow produces immature blood cells often referred to as stem cells, progenitor cells, or blasts (Aggarwal, S., Van de Loosdrecht, A., Alhan, C., Ossenkoppele, G. J.,Show MoreRelatedRationale : Myelodysplastic Syndrome ( Mds )1999 Words   |  8 PagesRationale: Myelodysplastic syndrome (MDS) is not something that is common throughout my family, but since most of our medical conditions were commonalities with the rest of the United States population, I took a particular interest in this unusual condition. My paternal grandfather – a farmer and a military veteran – was diagnosed with acute myeloid leukemia in 1996 at the age of 72, which was his cause of death in 1999. Several years prior to this he was diagnosed with what was once referred toRead MoreDiagnosis And Classification Of Myeloproliferative And Myelodysplastic Disorders1678 Words   |  7 PagesMyeloproliferative and myelodysplastic syndromes, two diverse groups of bone marrow disorders, are respectively characterized by an overproliferation or ineffective production of various blood cells. The clinical laboratory plays a prominent role in the diagnosis and classification of myeloproliferative and myelodysplastic disorders, each of which presents a unique set of morphologic, pathophysiologic, and genetic traits. The contemporary diagnosis and categorization of these syndromes emphasizes a combinationRead MoreMyelodysplastic Syndromes Are A Group Of Disorders Caused By Poorly Formed Or Dysfunctional Blood Cells1508 Words   |  7 Pagesâ€Å"Myelodysplastic syndromes are a group of disorders c aused by poorly formed or dysfunctional blood cells.† (Mayo Clinic 2015) Myelodysplastic syndromes, also known as bone marrow failure syndromes, occur when the bone marrow is not doing its job of providing enough functional, healthy blood cells. These syndromes generally occur with geriatric patients, and are responsible for a host of issues such as abnormal bleeding, infection, bruising, and anemia. People with these syndromes generally presentRead More5-Azacytidine is a Potential Chemotherapeutic Agents for Cancer1430 Words   |  6 PagesIt is sold under the brand name Vidaza. The drug was first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer. It is an inhibitor of DNA methylation and was approved by the US FDA for the treatment of Myelodysplastic syndromes (MDS) in May 2004. MDS are diseases caused by abnormalities in the blood-forming cells of the bone marrow, which result in low production of healthy blood cells. Cytotoxic effect is exerted on rapidly dividing cancerous cells by the drug. This restoresRead MoreAzacitidine are DNA Methyltransferase Inhibitors641 Words   |  3 Pagesan analog for cytidine gets integrated into the DNA sequence of the DNMT gene, the gene turns dysfunctional, inhibiting the DNA methyltransferase enzymes which normally methylate DNA. Azacitidine is used primarily for the treatment of myelodysplastic syndromes or MDS- a blood disorder which affects the bone marrow leading to a low or ineffective production of blood cells. The cancerous overgrowth of a number of immature cells or blasts and the abnormally developed or dysplastic cells increase, therebyRead MoreTaking a Look at Myelodysplasia Syndrome1160 Words   |  5 PagesMyelodysplasia syndrome (MDS), is a type of disease that is associated with abnormal cells in the blood and bone marrow. Patients with the disease commonly have immature stem cells which result in unhealthy progenies such as platelets, red and white blood cells. There are different types of MDS, which are analyzed by certain changes in the blood or bone marrow. MDS can be more commonly found in Men in their 60’s seeing how the chances of myelodysplasia syndrome increases with age. Genetics alsoRead MoreEssay on Hematology1016 Words   |  5 PagesParoxysmal Nocturnal Hemoglobinuria (PNH) also known as Marchiafava-Micheli Syndrome (named after Dr. Ettore Marchiafava and Dr. Ferdinando Micheli) For every million people only a few of them will get paroxysmal nocturnal hemoglobinuria which makes this a rare blood disease. Paroxysmal nocturnal hemoglobinuria affects both sexes and all ages equally. Patients with PNH suffer from a faulty or missing PGI-A gene which can be found within the erythrocytes, leukocytes, and thrombocytes. ParoxysmalRead MoreProstate Cancer : A Common Type Of Cancer914 Words   |  4 Pagesthe other testicle. In fact, men who treated their cancer with surgery alone, have a greater chance of getting a second testicular cancer than those who were treated with chemotherapy. However, there is an increased risk of leukemia and myelodysplastic syndrome (MDS) after receiving treatment with chemotherapy. Also, testicular cancer survivors are twice as likely to develop a new cancer outside of the testicles than those who never had it. Some examples of such cancers are: rectal, pancreas, bladderRead MoreAll And Its Effects For Lymphoblasts1355 Words   |   6 Pagesto treat other cancers, and -cancer-causing substances in tobacco smoke.Some people with pre-existing blood disorders like certain myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN), or certain genetic disorders like Downs Syndrome, Bloom Syndrome and Fanconis anaemia may have a higher than average risk of developing AML. What are the symptoms? Read MoreChemical Surveillance Program For Leukemia1184 Words   |  5 PagesGrandbastien, B., Preudhomme, C., Fontaine, B., Brillet, J. M., . . . Fenaux, P. (2001). Occupational and environmental risk factors of the myelodysplastic syndromes in the North of France. British Journal of Haematology Br J Haematol, 112(4), 927-935. doi:10.1046/j.1365-2141.2001.02645.x Pagano, L., Caira, M., Fianchi, L.., Leone, G., (2006). Environmental risk factors for MDS/AML. Haematologica reports. 2(15), 42-45. Checkoway, H., Eisen, E. A. (1998). Developments in Occupational Cohort Studies